Deep Vein Thrombosis (DVT)

Pathophysiology

DVT occurs when a blood clot forms in the deep veins of the legs, typically in the calf or thigh due to Virchow's triad: venous stasis, endothelial injury, and hypercoagulability.

Clinical Manifestations

Pain or tenderness in one leg
Swelling of the affected leg
Redness or discoloration
Warmth in the affected area

Treatment Strategies

Anticoagulants

Thrombolytic Therapy

Compression Stockings

IVC Filters

Diagnostic Approaches

D-dimer Test

Compression Ultrasound

Venography

Transforming DVT Care Through Advanced Clot Removal

Deep Vein Thrombosis (DVT) affects over 1 million Americans annually, with up to 50% of patients developing post-thrombotic syndrome (PTS)—a debilitating condition marked by chronic pain, swelling, and ulcers. Mechanical thrombectomy has emerged as a game-changing intervention, offering rapid clot removal, reduced long-term complications, and improved quality of life. This paper explores the benefits of mechanical thrombectomy, focusing on evidence from clinical studies and real-world applications.

Limitations of Traditional DVT Treatments

Anticoagulation (AC)

While AC prevents clot propagation, it does not address existing thrombus, leaving patients at risk for post-thrombotic syndrome (PTS).

Catheter-Directed Thrombolysis (CDT)

CDT dissolves clots using thrombolytic drugs but carries significant bleeding risks (e.g., intracranial hemorrhage) and is contraindicated in 40% of patients due to recent surgery, stroke, or advanced age.

Treatment Limitations

CDT requires prolonged ICU monitoring and is ineffective for older, organized clots. This leaves many patients without effective treatment options.

DVT affects over 1 million Americans annually, with up to 50% of patients developing post-thrombotic syndrome (PTS)—a debilitating condition marked by chronic pain, swelling, and ulcers.

Mechanical Thrombectomy for DVT

How It Works

Mechanical thrombectomy devices, such as the ClotTriever System, physically remove thrombus via minimally invasive techniques. A large-bore sheath with an integrated funnel facilitates thrombus extraction, while a nitinol coring element dislodges clot, which is captured in a mesh bag for removal.

Superior Thrombus Clearance

The CLOUT Registry (500 patients) demonstrated mechanical thrombectomy achieved 92.5% venous flow restoration and 91.8% venous compressibility at 6 months, compared to 27.2% at baseline. Mid-Term Outcomes showed a 94.6% recanalization rate in percutaneous thrombectomy studies.

Reduced Risk of Post-Thrombotic Syndrome

Median Villalta scores (PTS severity) dropped from 9.0 (moderate PTS) to 1.0 (asymptomatic) at 6 months post-thrombectomy. Patients report 83% reduction in pain and 76% improvement in swelling.

Find out if you are a candidate

Take Risk Assessment Now

Benefits of Mechanical Thrombectomy for DVT

Single-Session Treatment

0 %

Of ClotTriever cases require only one procedure, avoiding multi-day infusions

Hospital Days

Average hospitalization vs. 5-7 days for CDT

Readmission Rate

< 0 %

30-day VTE-related readmission rate

Device-Related SAEs

0 %

Extremely low serious adverse event rate

Mechanical thrombectomy has emerged as a game-changing intervention, offering rapid clot removal, reduced long-term complications, and improved quality of life without the bleeding risks associated with thrombolytic therapy.